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The COVID-19 pandemic was confirmed to have spread to the West Bank on 5 March 2020, beginning the COVID-19 pandemic in Palestine. The Palestinian health ministry said the cases had first been detected at a hotel in the Bethlehem area, where a group of Greek tourists had visited the hotel in late February, with two later diagnosed with the virus.

The first two cases in Gaza City, Gaza were diagnosed on 21 March. On August 24, 2020, confirmed cases outside of quarantine centers were recorded. On 31 August 2020, according to United Nations Humanitarian Coordinator Jamie McGoldrick, “The deterioration witnessed in recent weeks in the Gaza Strip is of grave concern,” Power cuts are severely affecting hospitals as well as critical infrastructure. The Hebron district is currently an epicenter.

The city of Bethlehem became the first to experience an outbreak with confirmed cases in early March. The City of Bethlehem was locked down on March 7 as 16 cases of infection were found in the West Bank, including nine cases in Bethlehem. The crowded Palestinian refugee camps face a grave threat if coronavirus spreads. On April 22, a Palestinian from Syria became the first case reported in a refugee camp, located in the Wavel refugee camp in Bekaa, Lebanon. On April 24, the Palestinian Ministry of Foreign Affairs and Expatriates (FAE) confirmed 4 more cases in Al-Jalil refugee camp, raising the total to five.

Between Monday, July 20 and Tuesday, July 21, 2020, East Jerusalem registered the highest number of cases since the beginning of the pandemic. Cases in East Jerusalem total 1,721, according to the Israeli Health Ministry and municipality. The IDF Home Front Command is in charge in East Jerusalem but since some residents go to Palestinian clinics for testing there is some uncertainty about total numbers. As of 1 September 2020 there were 0 new cases reported for a total of 7209, 1734 active and 21 fatalities. As of 2 September 2020 there were 249 new cases reported for a total of 7458, 1861 active and 22 fatalities. As of 3 September 2020 there were 0 new cases reported and figures remained unchanged.

13 September  Mai Alkaila confirmed 811 new cases, 370 recoveries and 12 fatalities. 37 patients are in intensive care, 9 on respirators. Ghassan Nemer, spokesman for the Ministry of Interior, said a return to full lockdown was possible due to a surge in cases, resulting from a lack of adherence to safety protocols but for the time being stricter implementation is being recommended.As of 21 September 2020 there were 146 new cases reported for a total of 9906, 1830 active and 44 fatalities. As of 22 September 2020 there were 128 new cases reported for a total of 10034, 1856 active and 45 fatalities.

As of 23 September 2020 there were 0 new cases reported and figures remained unchanged. As of 24 September 2020 there were 205 new cases reported for a total of 10239, 1790 active and 48 fatalities. The FAE announced 500 cases and 23 deaths among Palestinians in the diaspora, including 349 cases and 15 deaths in the United States. The ministry noted that around 1,000 Palestinian doctors were participating in health efforts in Europe along with hundreds more in the US, Venezuela and Cuba among other states.

As of June 2, there were 1,793 cases, 112 deaths and 946 recoveries, according to FAE. On June 17, 2020, FAE confirmed 30 new cases in the diaspora for a total of 2078 and two deaths for a total of 142.] On 24 June 2020, the FAE confirmed 3,801 cases and 193 fatalities in the diaspora with 1,643 recoveries. On 5 September 2020, the FAE announced four new cases among Palestinians abroad raising the total to 5817 while 1969 have recovered. Among total worldwide deaths of 244 a new death was recorded in Saudi Arabia bringing the total in that country to 79. The four new cases were recorded in New York and New Jersey, bringing total cases among Palestinians in the US to 3526, while deaths stood at 74.